Isaac Guerendo may see his role diminish with the drafting of Jordan James, creating competition for snaps in the running back position after a promising rookie season.

Isaac Guerendo is poised to take on a larger role in the 49ers' backfield following Jordan Mason's trade.

Guerendo presents a strategic late-round option as he sits behind McCaffrey, particularly due to McCaffrey's injury history.

Isaac Guerendo has shown promise as a capable lead back for the 49ers amidst a tumultuous injury landscape. His late-season performances evidenced his potential to handle significant touches, making him a strategic buy for fantasy teams.

Isaac Guerendo presents an intriguing buy opportunity due to his pass-catching ability, which could lead to valuable fantasy points if he can secure a leading role in San Francisco's offense.