Isaac Guerendo has emerged as a promising running back for the San Francisco 49ers, averaging 5.0 yards per carry last season. His performance during injuries to main players shows he can step up when needed. With McCaffrey's injury history, he could be a valuable fantasy asset in upcoming seasons.

Guerendo is positioned as a sleeper pick for 2025 fantasy football drafts, having showcased impressive skills last season as the 49ers' RB1. He averaged 5.0 yards per carry and forced numerous missed tackles, indicating potential for a breakout year.

Isaac Guerendo is emerging as a potential breakout RB, which could make him a sneaky pick in drafts. His role in the 49ers' offense could lead to significant fantasy contributions.

Isaac Guerendo offers intriguing upside as a backup running back for the San Francisco 49ers. His speed and agility could make him a valuable asset if given an opportunity to step into a larger role.

Isaac Guerendo is competing with Jordan James for the backup position on the 49ers, showing potential during his rookie season but needs to outperform James in training camp to secure a role.